Association of prematurity with complications and failure to rescue in neonatal surgery

Abstract

BackgroundThe majority of failure to rescue (FTR), or death after a postoperative complication, in pediatric surgery occurs among infants and neonates. The purpose of this study is to evaluate the association between gestational age (GA) and FTR in infants and neonates. MethodsNational cohort study of 46,452 patients < 1 year old within the National Surgical Quality Improvement Program–Pediatric database who underwent inpatient surgery. Patients were categorized as preterm neonates, term neonates, or infants. Neonates were stratified based on GA. Surgical procedures were classified as low- (< 1% mortality) or high-risk (≥ 1%). Multivariable logistic regression and cubic splines were used to evaluate the association between GA and FTR. ResultsPreterm neonates had the highest FTR (28%) rates. Among neonates, FTR increased with decreasing GA (≥ 37 weeks, 12%; 33–36 weeks, 15%; 29–32 weeks, 30%; 25–28 weeks 41%; ≤ 24 weeks, 57%). For both low- and high-risk procedures, FTR significantly (trend test, p < 0.01) increased with decreasing GA. When stratifying preterm neonates by GA, all GAs ≤ 28 weeks were associated with significantly higher odds of FTR for low- (OR 2.47, 95% CI [1.38–4.41]) and high-risk (OR 2.27, 95% CI [1.33–3.87]) procedures. A lone inflection point for FTR was identified at 31–32 weeks with cubic spline analysis. ConclusionsThe dose-dependent relationship between decreasing GA and FTR as well as the FTR inflection point noted at GA 31–32 weeks can be used by stakeholders in designing quality improvement initiatives and directing perioperative care. Level of evidenceLevel IV, Retrospective cohort study