Abstract
Peroxisome Proliferator-Activated Receptors gamma (PPARG) are widely known to substantiate their role in T2DM and T2DM complications. The study was conducted to understand the association of PPARG (rs1801282) genetic polymorphisms and obesity with T2DM in Bengalee Hindu caste population of West Bengal, India. A total of 104 clinically diagnosed Type 2 diabetes mellitus male patients (age range = 23–80 years) and 176 apparently healthy males (age range = 18–79 years) without T2DM from an endogamous linguistic group (Bengalee Hindu caste population) were participated. Genomic DNA was extracted from mouthwash and genotyping was performed by using PCR-RFLP method. Standard protocol has been used for collection of data on anthropometric and physiological variables. PPARG (rs1801282) genetic polymorphism have not any effect (p = .757) on T2DM progression and obesity between the genotypes (CC vs CG). However, CG genotype revealed higher (p < .05) Percent Body Fat, Waist Circumference and Hip Circumference in T2DM patients compared to controls with CG genotype. That may induce T2DM risk not directly but mediated through obesity.
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