Abstract
Background: The association between paraoxonase 2 (PON2) gene polymorphisms and type 2 diabetes mellitus (T2DM) has been extensively investigated in the Chinese population with conflicting results. In this study, we systematically evaluated the association between PON2 Ser311Cys and Ala148Gly polymorphisms and T2DM risk by pooling all relevant studies.Methods: We searched PubMed, Embase, CNKI, and Wanfang databases for the studies. The strength of association was determined by the allelic, homozygous, heterozygous, recessive, and dominant genetic models and measured as odds ratio (OR) and 95% confidence interval (CI), under fixed- or random-effect models.Results: There was no significant association between PON2 Ser311Cys polymorphism and T2DM under any of the genetic models: allelic (OR = 1.06, 95% CI = 0.77–1.45; P = 0.721), heterozygous (OR = 1.13, 95% CI = 0.87–1.45; P = 0.362), dominant (OR = 1.10, 95% CI = 0.80–1.51; P = 0.562), recessive (OR = 0.87, 95% CI = 0.48–1.58; P = 0.648), homozygous (OR = 0.94, 95% CI = 0.47–1.89; P = 0.865). Similarly, no significant association was found in PON2 Arg148Gly polymorphism under any of the models: allelic (OR = 1.17, 95% CI = 0.91–1.50; P = 0.218), heterozygous (OR = 1.28, 95% CI = 0.94–1.74; P = 0.117), dominant (OR = 1.25, 95% CI = 0.93–1.67; P = 0.142), recessive (OR = 0.99, 95% CI = 0.52–1.88; P = 0.973), homozygous (OR = 1.08, 95% CI = 0.57–2.07; P = 0.808).Conclusions: The PON2 Ser311Cys and Ala148Gly polymorphisms were not associated with the risk of developing T2DM in the Chinese population.
Highlights
Diabetes is a major cause of mortality and morbidity worldwide, and it has become an important public health problem in China [1, 2]
A total of 12 eligible studies were included for meta-analysis of paraoxonase 2 (PON2) Ser311Cys polymorphism [15,16,17,18,19, 24,25,26,27,28,29,30], and 4 studies for meta-analysis of PON2 Arg148Gly polymorphism [17, 31,32,33]
This is the first comprehensive metaanalysis to assess the genetic association between PON2 Ser311Cys and Ala148Gly polymorphisms and Type 2 diabetes mellitus (T2DM) risk in the Chinese population
Summary
Diabetes is a major cause of mortality and morbidity worldwide, and it has become an important public health problem in China [1, 2]. National surveys indicate that the prevalence of diabetes increased dramatically among Chinese adults during the past three decades. Type 2 diabetes mellitus (T2DM) is the most prevalent type of diabetes around the world. The PON2 gene contains eight introns and nine exons. It is polymorphic and several common single nucleotide polymorphisms (SNP) have been identified far. Genetic variations in PON2 gene may be associated with a number of disorders, such as cardiovascular disease and T2DM [11,12,13,14]. The association between paraoxonase 2 (PON2) gene polymorphisms and type 2 diabetes mellitus (T2DM) has been extensively investigated in the Chinese population with conflicting results. We systematically evaluated the association between PON2 Ser311Cys and Ala148Gly polymorphisms and T2DM risk by pooling all relevant studies
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