Abstract
Objective:Breast cancer is the most common cancer in American women, except for skin cancers. In this meta-analysis, the associations of polymorphisms within paraoxonase 1 (PON1), leptin (LEP) and leptin receptor (LEPR) genes with susceptibility to breast cancer were comprehensively evaluated. Methods:A universal search in PubMed, Scopus, CNKI, SID, Web of Knowledge and Google Scholar was performed to identify relevant studies up to 01 May, 2021. The strength of the associations was estimated by Odds ratios (ORs) with 95% confidence intervals (95% CIs). Results:A total of 39 case-control studies including 7 studies with 2005 cases and 2748 controls were on PON1 rs662, 6 studies with 2,031 cases and 1,973 controls on PON1 rs854560, 12 studies with 3,444 cases and 3,583 controls on LEP rs7799039, and 14 studies with 5,330 cases and 6,188 controls on LEPR rs1137101 were selected. Pooled data showed that PON1 rs662 and rs854560 polymorphisms were associated with risk of breast cancer in overall population, but not LEP rs7799039 and LEPR rs1137101. Conclusions:Our pooled data revealed that the PON1 rs662 and rs854560 polymorphisms were significantly associated with an increased risk of breast cancer in the overall population. However, LEP rs7799039 and LEPR rs1137101 polymorphisms were not associated.
Highlights
Global facts and figures about the cancer revealed that breast cancer still key public health concern and leading cause of deaths among women globally (Jafari-Nedooshan et al, 2017; Moghimi et al., 2018)
Pooled data showed that paraoxonase 1 (PON1) rs662 and rs854560 polymorphisms were associated with risk of breast cancer in overall population, but not LEP rs7799039 and leptin receptor (LEPR) rs1137101
Our pooled data revealed that the PON1 rs662 and rs854560 polymorphisms were significantly associated with an increased risk of breast cancer in the overall population
Summary
Global facts and figures about the cancer revealed that breast cancer still key public health concern and leading cause of deaths among women globally (Jafari-Nedooshan et al, 2017; Moghimi et al., 2018). In developing countries, screening and paid little attention to fight with breast cancer is one of the lowest priorities in health policy makers (da Costa Vieira et al, 2017). Breast cancer is most likely triggered and/or promoted by multiple risk factors. The two strongest risk factors for breast cancer are gender and age (Feng et al, 2018). The etiological make-up of a heterogeneous and complex disease such as breast cancer is diverse and includes genetics and environmental factors.
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