Abstract
Early-onset colorectal cancer (EOCRC) is an increasing and worrisome entity. The aim of this study was to analyze its association with polyps concerning prognosis and surveillance. EOCRC cases were compared regarding the presence or absence of associated polyps (clinical and molecular features), during a minimum of 7 years of follow-up. Of 119 cases, 56 (47%) did not develop polyps (NP group), while 63 (53%) did (P group). The NP group showed a predominant location of the CRC in the rectum (50%), of sporadic cases (54%), and diagnosis at advanced stages: Only P53 and SMARCB1 mutations were statistically linked to this group. The P group, including mainly early-diagnosed tumors, was linked with the most frequent and differential altered chromosomal regions in the array comparative genomic hybridization. The two most frequent groups according to the follow-up were the NP group (40%), and patients developing polyps in the first 5 years of follow-up (P < 5FU) (34%) (these last groups predominantly diagnosed at the earliest stage and with adenomatous polyps (45%)). EOCRC with polyps that developed during the entire follow-up (PDFU group) were mainly located in the right colon (53%), diagnosed in earlier stages, and 75% had a familial history of CRC. Patients developing polyps after the first 5 years (P > 5FU) showed a mucinous component (50%). Our results show that the absence or presence of polyps in EOCRC is an important prognostic factor with differential phenotypes. The development of polyps during surveillance shows that it is necessary to extend the follow-up time, also in those cases with microsatellite-stable EOCRC.
Highlights
Colorectal cancer (CRC) is the second leading cause of cancer-associated decease in the western world with respect to both incidence and mortality rate and is the most common tumor type in both sexes combined in Western countries [1]
During our analysis of the development of polyps within Early-onset colorectal cancer (EOCRC), we found that this provided important information for the prognosis of patients
We are aware that a weakness of our study lies in the small subsets of the P and NP groups used for molecular analysis, our results showed interesting altered chromosomal regions that can serve as starting points for specific studies aimed at determining whether they can be used for the identification of suitable markers
Summary
Colorectal cancer (CRC) is the second leading cause of cancer-associated decease in the western world with respect to both incidence and mortality rate and is the most common tumor type in both sexes combined in Western countries [1]. The incidence of early-onset CRC (EOCRC) has been rising during the last decades, compared with onset in patients older than 49 years old; in this latter group, it has decreased, together with cancer-associated mortality, in the USA [2]. During the most recent decade of available data, CRC incidence rates have uniquely increased in young adults in countries, such as Germany, the UK, Denmark, Slovenia, and Sweden, while CRC declined in young adults in only three countries (Italy, Austria and Lithuania); in Cyprus, the Netherlands, and Norway, inclines in the incidence in young adults were twice as rapid as those in older adults [7]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
