Abstract
Abstract. Mammalian decorin (DCN) consists of a protein core and a single dermatan or chondroitin sulfate glycosaminoglycan chain (CHOPRA et al. 1985), contributing multifunctionally to processes like matrix assembly, modulation of the activity of growth factors and cell migration and proliferation. Recently, LINDA et al. (2008) have reported that eight SNPs were identified in human. However, the related information in bovine is scarce. Hence, in the present experiment the exons and intron/exon boundaries of DCN were scanned for SNPs in the predominant cattle breeds of China.
Highlights
Mammalian decorin (DCN) consists of a protein core and a single dermatan or chondroitin sulfate glycosaminoglycan chain (CHOPRA et al 1985), contributing multifunctionally to processes like matrix assembly, modulation of the activity of growth factors and cell migration and proliferation
SSCP polymorphisms were detected in D2, D3, D5 and D9 fragments of the bovine DCN gene in 408 individuals belonging to three Chinese genetic types: 68 Qinchuan cattle, 240 Nanyang cattle and 100 Jiaxian cattle
Genotype A2A2 and haplotype A2 were more prevalent and only Nangyang cattle significantly deviated from the Hardy-Weinberg equilibrium (P
Summary
Mammalian decorin (DCN) consists of a protein core and a single dermatan or chondroitin sulfate glycosaminoglycan chain (CHOPRA et al 1985), contributing multifunctionally to processes like matrix assembly, modulation of the activity of growth factors and cell migration and proliferation. D3: F 5’-TTT AAT GAC TGC GTG TTG CT-3’ R 5’-GCT TTA CTC CAT CAC TCC CT-3’ D5: F 5’-GCA GTT TCC TCA GGT TGT CC-3’ R 5’-ACC CGT GGC TGA TTC AAG TC-3’ D9: F 5’-TTT CCC ACA TGA CTT ATT-3’ R 5’-TTA CAT AGC CTG GAT TGA-3’
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