Abstract
Aim Psoriasis is a chronic inflammatory disease with a complex etiology, and psoriasis vulgaris (PsV) is the most common type of psoriasis. Recent studies suggest the relationship between psoriasis and metabolic syndrome in different ethnicities. This study is aimed at evaluating the association of metabolism-related gene variants with the risk of PsV in Chinese Han population. Material and Methods. PsV patients (1030) and healthy controls (965) were enrolled in this study. Eighteen single-nucleotide polymorphisms (SNPs) previously reported to be significantly associated with metabolic syndrome were selected. SNPs were detected by next-generation sequencing. Results Seven SNPs were significantly associated with PsV: rs805303 (P = 0.012, OR = 0.85), rs3177928 (P = 1.37 × 10−15, OR = 2.51), and rs2247056 (P = 3.73 × 10−4, OR = 0.67) located in the HLA gene region; rs1047781 (P = 0.012, OR = 1.18), rs281379 (P = 0.014, OR = 1.71), and rs492602 (P = 0.005, OR = 1.86) located in the FUT2 region; and rs2303138 (P = 0.014, OR = 1.18) located in the LNPEP region. After stratified analysis, rs805303 (P = 0.017, OR = 0.74) and rs2303138 (P = 0.041, OR = 1.30) were associated with PsVs when HLA-C∗06 : 02 was positive, and rs805303 (P = 5.62 × 10−5, OR = 0.68), rs3177928 (P = 0.003, OR = 1.75), rs281379 (P = 0.034, OR = 1.96), and rs492602 (P = 0.025, OR = 2.04) were associated with PsVs when HLA-C∗06 : 02 was negative. Conclusion PsV and metabolic syndrome may have overlapped susceptible genes in Chinese Han population.
Highlights
Psoriasis is a chronic inflammatory disease caused by various factors including genetic factors, with psoriasis vulgaris (PsV) representing the most common type [1]
Angiotensin II type 1 receptor (AT1R) is correlated with hypertension, heart disease, and oxidative stress, and Mohammadi et al reported that AT1RA1166C polymorphism significantly increased the risk of psoriasis [4]
We investigated 18 polymorphisms reported in previous studies to be associated with metabolic syndrome and examined them in a Chinese Han population
Summary
Psoriasis is a chronic inflammatory disease caused by various factors including genetic factors, with psoriasis vulgaris (PsV) representing the most common type [1]. It is reported that psoriasis is related to metabolic syndrome. The association of metabolic syndromes such as dyslipidaemia, hypertension, insulin resistance, and abdominal obesity with psoriasis has been investigated. A metaanalysis of the association of angiotensin-converting enzyme (ACE) gene polymorphisms with psoriasis susceptibility showed that the polymorphisms were associated with the risk of psoriasis in Asians [3]. Angiotensin II type 1 receptor (AT1R) is correlated with hypertension, heart disease, and oxidative stress, and Mohammadi et al reported that AT1RA1166C (rs5186) polymorphism significantly increased the risk of psoriasis [4]. Cheng et al found that rs2303138 polymorphism in the LNPEP gene was associated with renin angiotensin and played a key role in cardiovascular disease and diabetes mellitus [5]
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