Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients.

Won Kyoung Cho,Kyoung Soon Cho,Byung-Kyu Suh,Min Ho Jung,Jung-Pil Jang,So Hyun Park,Tai-Gyu Kim,In Cheol Baek,Moonbae Ahn,Shin Hee Kim,Eun-Jeong Choi

doi:10.1155/2017/2304218

Abstract

Background Toll-like receptors (TLRs) have been suggested to be associated with the development of AITD. Methods Fifteen single-nucleotide polymorphisms in 7 TLR genes were analyzed in 104 Korean children (girls = 86, boys = 18) with AITD (Hashimoto disease (HD) = 44, Graves' disease (GD) = 60, thyroid-associated ophthalmopathy (TAO) = 29, and non-TAO = 31) with 183 controls. Results GD showed higher frequencies of the TLR4 rs1927911 C allele than control. TAO showed a lower frequency of the TLR4 rs1927911 CT genotype and non-TAO showed a higher frequency of the TLR4 rs1927911 CC genotype than control. The frequency of the TLR9 rs187084 CC genotype in TAO was higher than that in non-TAO. GD females showed a higher frequency of the TLR4 rs10759932 T allele, rs1927911 CC genotype, and the rs1927911 C allele than controls. GD males showed a higher frequency of the TLR4 rs10759932 CC genotype and rs1927911 TT genotype and lower frequency of the rs1927911 CT genotype than control. The frequency of the TLR4 rs10759932 CC genotype, C allele and rs1927911 TT genotype, and T allele in a GD female were lower than in a GD male. Conclusions Our results suggest that TLR4 and 9 polymorphisms might contribute to the pathogenesis of GD and TAO.

Highlights

It has been suggested that autoimmune thyroid disease (AITD) may occur when genetically susceptible individuals are exposed to environmental triggers such as infection, iodine, and stress [1]
We investigated the potential associations of seven Toll-like receptors (TLRs) genes (TLR1, 2, 3, 4, 5, 6, and 9) including 15 single-nucleotide polymorphisms (SNP) with AITD in Korean children
When AITD were categorized by the disease subgroup, Graves’ disease (GD) showed higher frequencies of TLR4 rs1927911 C allele (OR = 1.56; 95% CI, 1.0–2.4, P = 0 046) than those by the control group (Table 3)

Summary

Background

Toll-like receptors (TLRs) have been suggested to be associated with the development of AITD. GD showed higher frequencies of the TLR4 rs1927911 C allele than control. TAO showed a lower frequency of the TLR4 rs1927911 CT genotype and non-TAO showed a higher frequency of the TLR4 rs1927911 CC genotype than control. The frequency of the TLR9 rs187084 CC genotype in TAO was higher than that in non-TAO. GD females showed a higher frequency of the TLR4 rs10759932 T allele, rs1927911 CC genotype, and the rs1927911 C allele than controls. GD males showed a higher frequency of the TLR4 rs10759932 CC genotype and rs1927911 TT genotype and lower frequency of the rs1927911 CT genotype than control. The frequency of the TLR4 rs10759932 CC genotype, C allele and rs1927911 TT genotype, and T allele in a GD female were lower than in a GD male. Our results suggest that TLR4 and 9 polymorphisms might contribute to the pathogenesis of GD and TAO

Introduction

Subjects and Methods

Results

Discussions