Association of polymorphisms in LEPR with type 2 diabetes and related metabolic traits in a Chinese population

Lulu Zhang,Yingfen Qin,Lulin Chen,Hong Li,Li Li,Jia Zhou,Yaojie Liang,Lei Tong,Danyan Liang,Haiying Zhang

doi:10.1186/s12944-017-0644-x

Abstract

BackgroundLeptin acts as a mediator of inflammation and energy homeostasis by activating leptin receptor (LEPR). We conducted this study to explore the association of polymorphisms in LEPR with type 2 diabetes mellitus (T2DM) and its related metabolic traits.MethodsWe performed a case–control study to investigate the association of polymorphisms in LEPR with T2DM and related metabolic traits in a Chinese population, with a total of 922 T2DM patients and 1031 nondiabetic subjects. Polymorphisms were genotyped using MassARRAY assay.ResultsThe G allele of rs1327118 was associated with a decreased risk of T2DM in men (P = 0.044, odds ratio = 0.707, 95% confidence interval = 0.504–0.991) and the G allele of rs3806318 was associated with increased systolic blood pressure (SBP) in men with T2DM. Besides, the women patients carrying the G allele of rs1327118 showed increased SBP and diastolic blood pressure (DBP) levels, but decreased high density lipoprotein cholesterol (HDL-C) level.ConclusionOur results suggest that rs1327118 may be associated with SBP, DBP and HDL-C levels in women with T2DM, and rs3806318 may be associated with T2DM and SBP level in men with T2DM. Further studies with larger sample size or functional experiments focused on exact mechanism are required to verify our observations.

Highlights

Leptin acts as a mediator of inflammation and energy homeostasis by activating leptin receptor (LEPR)
The significant differences were found in Body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), HbA1C, high density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and TG between the two groups (P < 0.05), and there was no significant difference between the two groups in age, gender and low density lipoprotein cholesterol (LDL-C) level (P > 0.05)
Male individuals carrying G allele of rs1327118 showed a decreased risk of developing type 2 diabetes mellitus (T2DM) compared with C allele carriers (P = 0.044), whereas the CG and GG genotypes did not confer a risk to T2DM

Summary

Introduction

Leptin acts as a mediator of inflammation and energy homeostasis by activating leptin receptor (LEPR). We conducted this study to explore the association of polymorphisms in LEPR with type 2 diabetes mellitus (T2DM) and its related metabolic traits. Diabetes has become a serious public health concern around the world. In 2015, more than 415 million people suffered from diabetes and three quarters of diabetic patients lived in low and middle income countries. China has about 109 million patients with diabetes, and the number of patients is expected to increase to 151 million by 2040, of which type 2 diabetes mellitus (T2DM) accounts for about 95% [1]. Once secreted into the circulation, leptin reaches the central and peripheral nervous systems and acts by activating leptin receptor (LEPR) in the hypothalamus to alter the

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