Abstract
BackgroundSeveral case-control studies reported the relationship between single nucleotide polymorphisms (SNPs) in HSP70 genes and noise-induced hearing loss (NIHL). However, their conclusions are conflicting. This meta-analysis aims to identify the association of HSP70 variants and NIHL susceptibility.MethodA systematical literature search was performed in PubMed, Web of Science, EMBASE, and Wanfang Chinese database. The pooled odds radio (OR), 95% confidence interval (CI) and p value were calculated in fixed- or random-effects model according to the I2 value in the heterogeneity test.ResultsFour articles containing five studies, including 633 cases and 926 controls, were included. Under the allele, homozygote and dominant model, the pooled ORs (95%CI, p-value) of rs1061581 were 1.32 (1.06–1.67, p = 0.019), 1.93 (1.10–3.36, p = 0.021) and 1.455 (1.408–2.019, p = 0.025), respectively. In addition, a significant association was found between rs2227956 in Caucasians and the NIHL susceptibility under all five genetic models. We did not discover evidence sufficient to prove the associations between the other three SNPs (rs1043618, rs2763979 and rs2075800) and the NIHL susceptibility.ConclusionThis meta-analysis indicated that the two HSP70 variants, rs1061581 and rs2227956, may serve as genetic susceptibility factors for NIHL. Larger scale studies are required to further update the results.
Highlights
Noise is one of the most common sources of environmental stress in our contemporary society [1]
Several case-control studies reported the relationship between single nucleotide polymorphisms (SNPs) in heat shock protein 70kD (HSP70) genes and noise-induced hearing loss (NIHL)
We did not discover evidence sufficient to prove the associations between the other three SNPs and the Noise-induced hearing loss (NIHL) susceptibility. This meta-analysis indicated that the two HSP70 variants, rs1061581 and rs2227956, may serve as genetic susceptibility factors for NIHL
Summary
Noise is one of the most common sources of environmental stress in our contemporary society [1]. Several studies have suggested that this individual difference in susceptibility to NIHL is due to the diverse genetic background among individuals [6]. The genotypes or single nucleotide polymorphisms (SNPs) of some genes have been demonstrated to be related to individual NIHL susceptibility, such as SOD2 [7], GST [8], PCDH15 and MYH14 [9], but these genetic variations still cannot explain all individual differences. It is necessary to identify more NIHL-associated genes or genetic polymorphisms to further improve the genetic predictive system of NIHL. Several case-control studies reported the relationship between single nucleotide polymorphisms (SNPs) in HSP70 genes and noise-induced hearing loss (NIHL). This meta-analysis aims to identify the association of HSP70 variants and NIHL susceptibility
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