Association of Polymorphism GST1 Gene and Antioxidant status, and Interleukin-17 of Colorectal Cancer Iraqi Patients

Abstract

Colorectal cancer account as the third frequent carcinoma worldwide. It is expected that most cases of CRC occur sporadically (70–80%), while around 15% of CRC case resulted from inherited factors, such as familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal carcinoma (HNPCC). A total of (60) samples collected from Gastroenterology and Liver diseases teaching hospital from April 2018 to July 2018. The aim of this present study to was to detect association of polymorphism GST1 gene (on chromosome 20) with the risk of cancer Iraq patients and compare between GST1 gene of Iraq population with gene bank of NCBI. Examine oxidative stress and antioxidant status, and Interleukin-17 of Colorectal cancer patients. A significant decrease in the IL-17A and MDA levels were showed in control compared to patients. The levels of GSH show a highly significant change in control compared to patients. The results show substitution three Transversion G>C, one Transition G>A of GST1gene and showed 99% identified with a standard in Gene Bank from patients group while having 100% identified with a standard in Gene Bank with the control group.