Association of polymorphic variants of serotonin receptor genes, serotonin synthesis and metabolism enzymes genes with depressive disorder and clinical remission

N M Vyalova,G G Simutkin

doi:10.31363/2313-7053-2019-4-1-95-97

Abstract

The article presents the results of studies of associations of polymorphic variants of serotonin receptor genes and serotonin synthesis and metabolism enzymes genes with depressive disorders and the presence of clinical remission. The associations of polymorphic variants rs130058 of HTR1B gene and rs1176744 of HTR3B gene with depressive disorders was shown. Clinical remission assessed according to the CGI-S scale on the 28th day of therapy, associated with the polymorphic variant rs6298 of HTR1B gene, with remission in women, evaluated according to the HDRS-17 scale, associated polymorphic variants rs3813929 and rs1737429 of HTR2C gene. The data obtained confirm the participation of the serotonergic system in the pathogenesis of depressive disorders.

Highlights

The article presents the results of studies of associations of polymorphic variants of serotonin receptor genes and serotonin synthesis and metabolism enzymes genes with depressive disorders and the presence of clinical remission
Clinical remission assessed according to the Clinical Global Impression — Severity (CGI-S) scale on the 28th day of therapy, associated with the polymorphic variant rs6298 of HTR1B gene, with remission in women, evaluated according to the HDRS-17 scale, associated polymorphic variants rs3813929 and rs1737429 of HTR2C gene
The data obtained confirm the participation of the serotonergic system in the pathogenesis of depressive disorders

Summary

Introduction

The associations of polymorphic variants rs130058 of HTR1B gene and rs1176744 of HTR3B gene with depressive disorders was shown. Clinical remission assessed according to the CGI-S scale on the 28th day of therapy, associated with the polymorphic variant rs6298 of HTR1B gene, with remission in women, evaluated according to the HDRS-17 scale, associated polymorphic variants rs3813929 and rs1737429 of HTR2C gene. Депрессивные расстройства сопровождаются уменьшением активности серотонинергической системы, а также взаимодействиями полиморфных локусов генов серотонинового обмена, детерминирующими предрасположенность к развитию аффективных расстройств [5].

Results

Conclusion