Abstract
Aims. This study aimed to investigate whether the change of plasma myeloperoxidase (MPO) level would be associated with the incidence of coronary artery disease (CAD) among diabetic patients. Methods. 339 patients with type 2 diabetes mellitus (DM) underwent coronary angiography. Of them, 204 cases had CAD and were assigned to CAD group and 135 cases without CAD were assigned to non-CAD group. Results. Compared to non-CAD group, CAD group had higher level of plasma MPO (p < 0.01). Multiple linear regression analysis showed that plasma MPO level was correlated with Gensini score. Multiple logistic analysis showed that the odds ratios for CAD across increasing tertiles of MPO level were 1.191 (0.971–1.547) and 1.488 (1.115–2.228) (p = 0.048, p = 0.009 versus 1st tertile of MPO level, resp.) by adjusting for age, sex, and other conventional risk factors for CAD. The subjects were stratified into nine groups according to tertiles of MPO and HbA1c. The odds ratio for CAD was significantly higher in group with highest levels of MPO and HbA1c (OR = 4.08, p < 0.01). Conclusion. Plasma MPO level was positively correlated with the degree of coronary artery stenosis in type 2 diabetic patients, and increasing blood glucose might amplify the association between MPO and CAD.
Highlights
The incidence of cardiovascular disease among diabetic patients is 2–4 times higher than that in nondiabetic population
The MPO level was higher in diabetic patients than that in nondiabetic population [10,11,12], and increasing MPO levels were associated with greater progression of atherosclerosis in diabetic patients [13], but little is known about the association between MPO level and the presendence and severity of coronary artery disease (CAD) in subjects
Plasma MPO concentration was demonstrated to be significantly higher in diabetic patients with the complication of CAD than that in the non-CAD group
Summary
The incidence of cardiovascular disease among diabetic patients is 2–4 times higher than that in nondiabetic population. Clinical studies have shown that elevated blood MPO level was closely related to higher risk of coronary artery disease (CAD) [4] It could serve as a marker for the incidence of cardiovascular events [4,5,6]. Based on WHO diagnostic criteria for type 2 diabetes [15], we enrolled 382 patients with type 2 diabetes mellitus (DM) who were consecutively referred and underwent their first coronary angiography because of suspected coronary atherosclerosis at our hospital between April 2012 and October 2014 Those with medical illnesses such as unstable CAD, acute coronary syndrome, history of myocardial infarction, heart failure, infectious or inflammatory disease, chronic hepatic and renal dysfunction (including serum alanine aminotransferase > 120 IU/L, aspartate aminotransaminase > 80 IU/L, and serum creatinine > 2.0 mg/dL), and history of cerebral infarction were excluded. The study was approved by the Medical Ethics Committee of the Hospital, and all study subjects signed informed consent
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