Abstract
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease. IL-32, a secreted protein, has been reported to be associated with several autoimmune diseases. Our preliminary experiment showed different plasma IL-32 levels than that mentioned in a published report on the same population. In order to elucidate the correlation between IL-32 and SLE, we determined the plasma level and two single nucleotide polymorphisms (SNPs) of IL-32 in 152 patients with SLE and 310 healthy controls and analyzed the relationship based on the clinical parameters. The results showed that plasma IL-32 levels in patients with SLE were markedly lower than that in the healthy controls. In the SLE group, patients with detectable IL-32 presented low serum C3 concentrations. Further studies indicated that the rs28372698 SNP was associated with the susceptibility to SLE. Taken together, our results suggested that IL-32 could possibly be a candidate marker to monitor SLE disease stability and screening in future.
Highlights
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease, which involves multiple organ and tissue injuries [1]
Plasma IL-32 levels of 104 patients with SLE and 107 healthy controls were measured by EnzymeLinked Immunosorbent Assay (ELISA)
IL-32 is considered as a proinflammatory cytokine, which is related to IL-1β, IL-18, IL-21, and IL-23
Summary
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease, which involves multiple organ and tissue injuries [1]. The prevalence rate of SLE is about 70 cases per 100,000 people in the Chinese population [2]. Zhang et al showed that serum IL32 level was not statistically different between patients with SLE and healthy controls in the Chinese population [14]. Our team showed that the plasma IL32 level in healthy controls was markedly different than that observed by Zhang et al (39.25 (21.00–70.46) pg/mL). Such a difference within the same population seemed abnormal. We aimed to better understand the correlation between SLE and IL-32 using serology and immunogenetics in a larger sample size of the Chinese population
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