Abstract
Background: The association and mechanism of PM2.5 exposure in personal level with lung function alternation are rarely reported among urban adults in China. Objectives: To evaluate potential effects of personal PM2.5 exposure on lung function in general urban adults and explore mediating role of oxidative stress in the association. Methods: A total of 7685 measurements were obtained from the Wuhan-Zhuhai cohort. Personal PM2.5 exposure levels were estimated through an estimated model developed in Wuhan. Mixed linear model with subject-specific random intercept was used to evaluated the association between personal PM2.5 exposure and lung function, as well as PM2.5 exposure and oxidative damage biomarkers (urinary 8-isoprostane and 8-hydroxy-2′-deoxyguanosine (8-OHdG)). Mediation analysis was conducted to investigate the role of urinary 8-isoprostane and 8-OHdG in the association between PM2.5 and lung function. Results: Each 10 μg/m3 increase of the previous-day personal PM2.5 was significantly associated with a -2.94 mL, -2.02 mL and -16.14 mL/s change in FVC, FEV1 and PEF, respectively (all P<0.05). The associations were more obvious among never smokers compared with current smokers. Seven days moving average of PM2.5 exposure showed the strongest effects on lung function parameters. Non-linear association was observed between 8-isoprostane and lung function. Among participants with low 8-isoprostane level (<73.02 ng/mmol Cr), each 10 μg/m3 increase of 7 days average PM2.5 was associated with 1.06% (0.17, 1.96) increase in urinary 8-isoprostane level, and 8-isoprotane meditated 5.24%, 12.05% and 5.21% of the association with FVC, FEV1 and PEF, respectively. No significant association or mediation effect was observed among participants with high 8-isoprostane level. No significant mediation effect of 8-OHdG was observed. Conclusion: Personal exposure to PM2.5 is associated with reduced pulmonary ventilation function. PM2.5-related declines in both FEV1 and FVC were stronger among never smokers than those among current smokers. And urinary 8-isoprostane partly mediated the associations.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
