Abstract
Association of Persistent Pulmonary Hypertension in Infants With the Timing and Type of Antidepressants In Utero
Highlights
Antidepressant exposure during pregnancy has been linked to increased risk of persistent pulmonary hypertension of the newborn (PPHN).[1]
We investigated the association by timing of antidepressant exposure as follows: early pregnancy and late pregnancy, and treatment was categorized into SSRI (ATC code N06AB) and non-SSRI (ATC code N06A excluding N06AB) antidepressants (Table 1)
Of 29 822 live-born singleton children born to mothers who used antidepressants, PPHN was identified among 79 children (2.6 per 1000 live births), in contrast to 1637 children (1.3 per 1000 live births) among the unexposed children (Table 2)
Summary
Antidepressant exposure during pregnancy has been linked to increased risk of persistent pulmonary hypertension of the newborn (PPHN).[1]. Risks after non-SSRI exposure and risks with timing of exposure in pregnancy across type of antidepressants have been insufficiently quantified or evidence remains conflicting.[2,3] Given that PPHN is a potentially lethal complication, more detailed information on trimester- and antidepressant type–specific risk is essential
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