Abstract
Objective: To study the prevalence of peripheral neuropathy and evaluate the clinical nerve dysfunction in patients with chronic kidney disease. Study Design: Prospective study Place and duration: Medical ward Mayo hospital, Lady Wllingdon Hospital and Nishtar Hospital Multan from March 2018 to May 2019. Methodology: Eighty patients of clinically and biochemically proven chronic kidney disease were selected for study. Non probability consecutive sampling was used. Patients were assessed or both sensory and motor nerve dysfunction. SPSS software was used for data analysis. Main variables of study were creatinine clearance and neuropathy of peripheral nerves. Results: Affected patients percentage with reference to overt and subclinical neuropathy was noted as 67.5%. Overt neuropathy and subclinical neuropathy observed as 35.2% and 64.8%, respectively. Patients affected with percentage with reference to the type of peripheral neuropathy were noted 67.5%. Sensory-motor, sensory and motor was observed as 31.5%, 14.8% and 53.7%, respectively. Conclusion: Peripheral neuropathy is highly associated with chronic kidney disease and severity and prevalence of neuropathy increases with worsening in renal failure. Early diagnosis and strict compliance required to overcome this condition. Keywords: Chronic Kidney disease, Peripheral neuropathy, Hemodialysis, Sensory nerve, Motor nerve. DOI : 10.7176/JMPB/60-03 Publication date :October 31 st 2019
Highlights
Chronic kidney disease is associated with peripheral neuropathy[1]
Affected patients with percentage with reference to overt and subclinical neuropathy was noted as n=54 (67.5%)
Overt neuropathy and subclinical neuropathy observed as n=19 (35.2%) and n=35 (64.8%), respectively
Summary
Patients would not come for examination of dysfunction of peripheral nerve supply until they looked for or asked for. In these days’ patients long term survival rate is improving because of latest advancement in medical treatment[2]. It is essential to know about complications of CKD, if patients survive for long time, peripheral neuropathy is one of common complications of CKD4. Signs and symptoms of CKD are in all cases but cases are different in nature[5]. Neuropathy is symmetrical, distal and mixed motor and sensory in nature affecting 65% CKD patients mostly lower limbs as compared to upper limb. Strict control on patient’s serum creatinine with on time dialysis and medical compliance reversal and progression of neuropathy is possible[6]
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