Abstract
Introduction Inflammation is widely recognized to play an important role in cancer progression and is related to thrombosis. Soluble P-selectin (sP-selectin) is one of several biomarkers that may be predictive of thrombosis in cancer. This study aimed to investigate the correlation between monocyte count and sP-selectin in various stages of nasopharyngeal carcinoma. Methods Fifty-five patients with nasopharyngeal carcinoma were divided into three groups according to nodal and distant metastasis (group of stages I-IVA, IVB, and IVC). Monocyte count was calculated from routine peripheral blood examination, while sP-selectin level was measured using commercial ELISA kit. Results The monocyte count of subjects in groups IVB and IVC was significantly higher compared to group I-IVA (707/μL versus 528/μL, p = 0.022; 841/μL versus 528/μL, p = 0.005). Plasma levels of sP-selectin in group IVC were higher than group I-IVA (59.5 ng/mL versus 41.97 ng/mL, p = 0.001) and group IVB (59.5 ng/mL versus 45.53 ng/mL, p = 0.007). In subjects with high monocyte count (>665/μL), there was moderate correlation between monocyte count and sP-selectin (r = 0.436, p = 0.022). Conclusion Advanced stages of nasopharyngeal carcinoma had higher levels of monocyte count and sP-selectin compared to earlier stages. Monocyte count was correlated with sP-selectin especially in high monocyte count subgroup.
Highlights
Inflammation is widely recognized to play an important role in cancer progression and is related to thrombosis
Nasopharyngeal carcinoma patients admitted to Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from April to November 2012, were included if meeting the following criteria: pathologically proven nasopharyngeal carcinoma according to World Health Organization (WHO) histological classification, no prior malignancy, no previous chemotherapy or radiotherapy, no concurrent infections, no diabetes, no heart failure, no kidney diseases, and without any antithrombotic therapy
We found that the mean levels of sP-selectin were 52.81 ng/mL and the median level of sP-selectin in patients with distant metastasis was 59.5 ng/mL putting them in a high risk of thrombosis
Summary
Inflammation is widely recognized to play an important role in cancer progression and is related to thrombosis. This study aimed to investigate the correlation between monocyte count and sP-selectin in various stages of nasopharyngeal carcinoma. Fiftyfive patients with nasopharyngeal carcinoma were divided into three groups according to nodal and distant metastasis (group of stages I-IVA, IVB, and IVC). The monocyte count of subjects in groups IVB and IVC was significantly higher compared to group I-IVA (707/μL versus 528/μL, p = 0.022; 841/μL versus 528/μL, p = 0.005). Advanced stages of nasopharyngeal carcinoma had higher levels of monocyte count and sP-selectin compared to earlier stages. Nasopharyngeal carcinoma is a unique malignancy showing a distinct racial and geographical distribution [1]. This type of malignancy is endemic in Southern China and the incidence is up to 25 per 100,000 persons. The overall survival rates of stages I, II, III, and IVA were not significantly different, suggesting the N stage as the key prognostic factor [5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
