Abstract
Association of periodontitis and chronic kidney disease in dogs
Highlights
Periodontal disease (PD) is the most common oral disease in dogs that affects both health and quality of their life [1]
In view of the causative association between periodontal infection, generalized inflammation and important systemic diseases like chronic kidney disease, we hypothesize that targeted prophylaxis and careful treatment of oral diseases can prevent the progression of renal failure
PD severity among dogs in the present study was associated with increasing risk of azotemic chronic kidney disease (CKD), previous longitudinal study in dogs reported a significant relationship between the severity of PD and non-specific biomarkers of inflammation such as white blood cell count and the percentage of monocytes in peripheral blood [13]
Summary
Periodontal disease (PD) is the most common oral disease in dogs that affects both health and quality of their life [1]. PD is defined as a plaque-inducing disease of any part of the periodontium, which includes the gingiva, periodontal ligament and alveolar bone [1]. It is considered as a factor that predisposes patients to bacteraemia [2]. In dogs suffering from periodon-titis, concurrence of kidney disease with periodontitis is considered a consequence of low-grade bacteraemia associated with periodontal disease [3]. Several studies have evaluated the relation between PD and chronic renal failure in humans [4]. PD has been related to morphological changes in renal glomeruli and interstitium [3]. There is some controversy between reported findings in dogs' relation between PD and chronic renal failure [2, 4]
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