Association of Periodontal Disease with Serum Uric Acid and CRP in Patients Treated for Acute Coronary Syndrome: A Comparative Study

Abstract

Background: Periodontal diseases (PED) are a widespread, complicated, long-lasting inflammation of the gum. In recent years, lots of lines of evidence have confirmed the existence of an interrelated link between PED and systemic illnesses including acute coronary syndrome (ACS). In the pathogenesis of ACS, the persuasive inflammatory role of coronary vessels is well documented. An increasing body of evidence highlights the impact of UA in inflammation. C-reactive protein (CRP) is an acute phase reactant well-known as a nonspecific marker for systemic and vascular inflammation. The study intended to evaluate the associations of PED with SUA and CRP in patients treated for ACS in a comparative study. Methodology: 136-patients registered in this comparative study labeled as ACS besides 74-controls. The blood analysis of creatinine, urea, SUA and CRP had done for the applicants. Oral examination for grades and severity of PED had performed, and the candidates were grouped accordingly. Statistical studies had attained using SPSS software (IBM), with a significance-value calculated at <0.05. Results: There was a significantly higher HSCRP levels with a higher nonsignificant SUA levels among the ACS group. Risk factors in terms of incidence of DM, hypertension, and smoking (except the BMI) were significantly higher among patients. More than 3/4th of the patients' group was suffering from generalized PED (74.3%), while 15.4% had a localized PED and only 9% had healthy periodontium. Meanwhile, about 2/3rd of the controls has normal periodontium. 18.4% vs. 75% had a mild, 25.7% vs. 4% had a moderate, and 21.3% vs. zero had a severe form of PED, in patients and control respectively. There was a significant worsening of PED in terms of severity and grading (p-0.001) with the increase of HSCRP levels, which is not the case for increased SUA. Conclusion: HSCRP levels were significantly higher among patients with ACS compared to healthy control. There was a significant worsening of PED in terms of severity and grading with the increase of HSCRP levels. This is not the case for increased SUA, which is not associated with poor periodontal status.