Association of p53 expression in various molecular subtypes of invasive breast carcinoma NOS

Abstract

Breast cancer is the second most common cause of mortality for women after heart disease. Consequently, stopping it is difficult at all times. Metastasis frequently occurs to distant organs such the liver, lung, and brain.All specimens from lumpectomies, simple and modified radical mastectomies, and trucut biopsies identified as Invasive Ductal Carcinoma Not Otherwise Specified at the Central Diagnostic Laboratory of the Pathology Department at tertiary care centre, were included in the study. Immunohistochemical markers were utilised and haematoxylin and eosin sections were examined.Association of p53 expression in various molecular subtypes of invasive breast carcinoma NOS. All lumpectomy specimens simple and modified radical mastectomy, trucut biopsies specimens diagnosed as invasive carcinoma breast not otherwise specified, submitted to the Department of Pathology, AJIMS, Mangalore for histopathological study are included in this study.Statistical analysis of the data was performed using SPSS 20.0.The continuous variables were presented as mean±SD. Categorical variables were presented in frequency and percentage. Categorical variables were analysed using Chi square test. A p value<0.05 was considered statistically significant.This study is on the expression of p53 in invasive ductal carcinoma of the breast type NOS and correlating it with different histological grades, tumour sizes, and molecular subtypes. This study showed expression of p53 is independent of molecular subtype.