Abstract
Numerous studies have investigated the risk of cancer associated with the polymorphism of p21 3′ UTR (rs1059234 C > T), but results have been inconsistent. We performed this meta-analysis to drive a more precise estimation of the association between this polymorphism and risk of cancer. A comprehensive search was conducted to identify all case-control studies of the rs1059234 C > T polymorphism of p21 3′ UTR and cancer susceptibility. A total of eleven eligible studies, including 3,099 cases and 4,354 controls, relating to the rs1059234 polymorphism of p21 3′ UTR to the risk of cancer were identified. Multivariate and univariate methods revealed no association between this polymorphism and cancer risk. However, subgroup analysis by cancer type suggested that rs1059234 C > T polymorphism was associated with increased risk of squamous cell carcinoma of the head and neck (SCCHN) (dominant model CT + TT vs. CC: OR = 1.51, 95% CI = 1.17–1.94). No significant association was found in other subgroup analyses. This meta-analysis suggested that rs1059234 polymorphism of p21 3′ UTR may be associated with increased SCCHN risk. And larger scale primary studies are required to further evaluate the interaction of p21 3′ UTR rs1059234 polymorphism and cancer risk in specific populations.
Highlights
Numerous studies have investigated the risk of cancer associated with the polymorphism of p21 3′ UTR, but results have been inconsistent
After title and abstract screening, 445 publications, which did not investigate the association between cancer risk and the polymorphism of interest, were excluded; and the remaining 55 publications were carefully reviewed according to the criteria described in the ‘materials and methods’ section
Previous studies evaluating the association between p21 3′ UTR rs1059234 polymorphism and cancer risk have provided inconsistent results, and most of these studies involved no more than a few hundred cancer cases, which is too few to assess any genetic effects reliably
Summary
Numerous studies have investigated the risk of cancer associated with the polymorphism of p21 3′ UTR (rs1059234 C > T), but results have been inconsistent. No significant association was found in other subgroup analyses This meta-analysis suggested that rs1059234 polymorphism of p21 3′ UTR may be associated with increased SCCHN risk. P21 is the main protein that is required after p53 activation in response to DNA damage It plays a crucial role in cell cycle control by inhibiting activities of cyclin E_CDK2 and cyclin A_CDK2 complexes. As a result, it leads to dephosphorylation of the RB protein (pRb), which induces G1 arrest conducting to DNA repair or apoptosis[4,5]. We performed a comprehensive meta-analysis to derive a more precise estimation of the relationship between p21 3′ UTR rs1059234 polymorphism and the risk of cancer
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