Abstract
It has been suggested that excess body weight could represent a risk factor for infertility outcomes. The present study aimed to evaluate the association of overweight and anovulation among infertile women with regular menstrual cycles. We conducted a retrospective case-control study with consistently anovulatory patients undergoing assisted reproduction treatment. The patients were stratified into normal weight (body mass index [BMI]: 18.5-24.9kg/m2) and overweight (BMI: 25.0-29.9kg/m2).Those with polycystic ovary syndrome or obesity were excluded. The groups were matched for age, duration of infertility, prolactin, follicle stimulating hormone (FSH), thydroid stimulating hormone (TSH), luteinizing hormone (LH), and estradiol levels. Overweight was significantly associated with anovulation, when using the World Health Organization (WHO) criteria for anovulation: progesterone levels > 5.65 ng/ml and ultrasonography evidence of follicle collapse (odds ratio [OR]: 2.69; 95% confidence interval [CI95%]: 1.04-6.98). Body mass index above the normal range jeopardizes ovulation among non-obese infertile women with regular menstrual cycles.
Highlights
Body mass index (BMI) is associated with risk for diabetes mellitus, arterial hypertension, obstructive sleep apnea, cancer, dyslipidemia, and cardiovascular disease.[1]
Overweight was significantly associated with anovulation, when using the World Health Organization (WHO) criteria for anovulation: progesterone levels > 5.65 ng/ml and ultrasonography evidence of follicle collapse
A total of 7,200 medical records of infertile female patients who underwent assisted reproduction treatment were retrieved from LabRep, a human reproduction public health service
Summary
Body mass index (BMI) is associated with risk for diabetes mellitus, arterial hypertension, obstructive sleep apnea, cancer, dyslipidemia, and cardiovascular disease.[1] Puberty, ovulation and reproductive function are biological events highly dependent on body energetic reserves. In this regard, variables such as weight, body composition, body fat distribution, and the effects of diet and physical exercise have been investigated in women with alterations in sexual maturation, menstrual cycle, and fertility.[2,3,4]. Ovulatory disorders represent 25 to 50% of all causes of infertility in women, and a significant proportion is directly or indirectly related to overweight and obesity.[8]
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