Association of ovarian follicular response and pregnancy rates in patients undergoing intrauterine insemination: the best next step in patients failing oral stimultion protocols

Abstract

77% of cycles. Administration of r-hCG prior to IUI resulted in a higher clinical pregnancy rate compared with spontaneous serum LH surge: 17% vs. 6.9%, P 1⁄4 0.049. A subgroup analysis suggested that this effect may be more powerful in patients stimulated with FSH: 18.7% vs. 2.8%, (P 1⁄4 0.017). Patients with 2 or more follicles larger than 16 mm were more likely to receive r-hCG than those with only 1 follicle (P 1⁄4 0.04), but pregnancy rates did not differ between these two groups. CONCLUSIONS: r-hCG administration is associated with an increased clinical pregnancy rate compared with spontaneous serum LH surge in subfertile couples undergoing COH-IUI (OR 2.78; 95% CI 1.4, 8.2) Our larger prospective study will determine whether this effect is more powerful in gonadotropin-stimulated cycles as compared to Clomipheneand Letrozole-stimulated cycles. SUPPORT: None.