Abstract
The TOF pilot study was funded by a grant from the Region of Southern Denmark: 11/13244, and grants from The Committee of Quality and Education in General Practice, The Region of Southern Denmark: J.nr 15/10562 and 14/43732. Joyce van Tunen was funded by the European Union Seventh Framework Programme (FP7-PEOPLE-2013-ITN;KNEEMO) under grant agreement no. 607510. The funding bodies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
Highlights
Quadriceps muscle weakness is associated with knee joint pain and may be an important yet modifiable risk factor for radiographic knee osteoarthritis (OA)
Adjusted odds of cardiovascular disease (CVD) increased for those with knee and hip sxOA and severe sxOA
Those with rOA in both hips were at increased odds of developing CVD
Summary
Quadriceps muscle weakness is associated with knee joint pain and may be an important yet modifiable risk factor for radiographic knee osteoarthritis (OA). African American and Caucasian men and women aged 45 years or older at study entry who were free of CVD (n 1⁄4 3,560) or diabetes (n 1⁄4 3,740) at baseline were included in analyses. Population-averaged models for non-normal (binomial) repeated measures using generalized estimating equations (GEE) were used to estimate odds ratios (OR) and 95% confidence intervals (CI) and determine associations between knee and hip OA measures and development of CVD and diabetes at a later follow up period. All models were adjusted for age, BMI, sex, race, and education (less than or at least High School [HS]); any self-reported knee or hip injury (depending on the OA outcome) during at least one time-point; enrollment cohort (original or enrichment); and years of follow-up from baseline
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