Abstract
To assess the hypothesis that combined Oral Contraceptive (OCs) increase the risk of cervical neoplasia, we conducted a multicenter Case-Control study in Mashhad, the capital of Khorasan province. Seventy-eight women with moderate to severe dysplasia at Pap smear as case group and one hundred fifty nine women with normal Pap smear were selected as the control group for evaluation. The both case and control groups were matched by age, parity and socioeconomic status. All of the women in this study were single partner as husband and no smoker. 30 percent of cases and 64.8 percent of controls were used OCs. The duration of OCs use was the same in both. The odds ratio for OCs consumption was 0.2 with 95% confidence interval 0.11-0.4 in Logistic regression analysis. In contrast to some other studies, our findings showed an association between OCs and cervical dysplasia and there was a protective effect of OCs for cervical dysplasia.
Highlights
Initial studies had explained the relationship of Oral Contraceptives (OCs) and cervical neoplasia[1,2,3,4] In two extensive reviews, It was conducted that a weak positive association seems to be emerging between OCs usage and the risk of cervical neoplasia but that association may be due to bias and confounding[5,6] In the other studies, this association has fallen into suspicion
Screening of cervical neoplasia with Papanicolau smear (Pap smear) is very useful for preventing of cervical cancer, it seems confounded for cervical neoplasia itself, because of Human Papilloma Virus (HPV) changes in cervical mucous[8,9,10]
To evaluate the hypothesis that OCs affect to cervical mucus and may create neoplasia, we conducted a multicenter Case-Control study involving patients with moderate to high grade changes in cervical mucus at Pap smear and were compared with controls in Mashad- the capital of Khorasan province
Summary
Initial studies had explained the relationship of Oral Contraceptives (OCs) and cervical neoplasia[1,2,3,4] In two extensive reviews, It was conducted that a weak positive association seems to be emerging between OCs usage and the risk of cervical neoplasia but that association may be due to bias and confounding[5,6] In the other studies, this association has fallen into suspicion. Molina and coworkers did not find any risk for neoplasia in women who ever used OCs after controlling for the possible confounder[7]. Screening of cervical neoplasia with Papanicolau smear (Pap smear) is very useful for preventing of cervical cancer, it seems confounded for cervical neoplasia itself, because of Human Papilloma Virus (HPV) changes in cervical mucous[8,9,10].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
