Abstract
Purpose: Breast cancer (BC) is globally the main reason of cancer-related deaths in women. Omentin-1, an anti-inflammatory and antioxidant adipokine, plays different roles in tumorigenesis and anti-oncogenic pathways. In present study, we investigated the association of omentin-1 with oxidative stress and clinical significances in healthy controls and BC patients to assess the prognostic and diagnostic value of omentin-1 in this cancer. Methods: This case-control study included 88 BC patients and 86 healthy controls. The serum levels of omentin-1 were assessed by enzyme-linked immunosorbent assays methods. Also, total antioxidant capacity (TAC), total oxidant status (TOS) and malondialdehyde (MDA) serum levels were measured by spectrophotometer. quantitative real-time polymerase chain reaction (qRT-PCR) was applied to the measurement of gene expression of omentin-1. Results: the serum levels of omentin-1 were significantly lower in the BC patients compared to the healthy controls (P<0.001). Moreover, gene expression of omentin-1was significantly downregulated in the BC tissues compared to the adjacent normal tissues (P<0.001). Gene expression of omentin-1and its serum levels were significantly higher in grade I compared with grade II and III (P=0.001, P<0.001, respectively). Additionally, the serum levels of omentin-1 in the p53-positive BC patients were significantly higher than the p53-negative BC patients (P=0.001). There was an inverse correlation between the serum levels of MDA and TOS with the serum levels of omentin-1 (r=-0.436, r=-461, respectively). Conclusion: We conclude that omentin-1 may have a good prognostic and diagnostic roles in the BC patients and decreases oxidative stress in these patients.
Highlights
Breast cancer (BC), as one of the most prevalent malignancies, is the main cause of cancer-related deaths in females worldwide.[1]
We investigated the association of omentin-1 with oxidative stress and clinical significances in healthy controls and BC patients to assess the prognostic and diagnostic value of omentin-1 in this cancer
Results: the serum levels of omentin-1 were significantly lower in the BC patients compared to the healthy controls (P < 0.001)
Summary
Breast cancer (BC), as one of the most prevalent malignancies, is the main cause of cancer-related deaths in females worldwide.[1]. Omentin-1 (intelectin-1 or intestinal lactoferrin receptor), a peptide with molecular weight of 34 kDa, is an anti-inflammatory and anti-insulin resistance adipokine synthesized abundantly in the visceral adipose tissue.[14] There are two homologous omentin isoforms known as, omentin 1 and omentin 2, which omentin-1, the principal circulating isoform in plasma, is decreased in obesity and diabetes patients.[15] According to in vivo studies, it has been suggested that omentin-1 is negatively correlated with oxidative stress and is being considered as a positive marker to prevent the damage caused by oxidative stressinduced diabetic nephropathy.[16]. We evaluated clinical significances and serum markers of oxidative stress and investigated the association of these parameters with the serum levels of omentin-1 and its gene expression in the tissue of women with BC to evaluate the prognostic and diagnostic value of omentin-1 in this cancer
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