Abstract
Objective: Prevalence of diabetes in Pakistan in the year 2014 was 6.9 million and is expected to rise to approximately 13 million in 2035, ranking Pakistan at 8th position among world's top 10 countries having diabetes. Materials and Methods: The study design is young subjects were taken aged 18 to 24 and were classified according to their family history of type 2 diabetes mellitus (T2DM) into those with single diabetic parent (SDP), both diabetic parents (BDP) and subjects having no family history of diabetes (NDP). Body composition was assessed by measuring body mass index (BMI), waist circumference (WC) and waist-hip ratio (WHR). Fasting venous blood was analyzed for glucose and leptin levels (measured by immunoenzymetric assay). Results: The offspring of BDP had significantly higher body weight as compared to those of SDP and NDP (p<0.05). The mean fasting serum leptin levels among NDP, SDP and BDP were significantly different (p<0.05), and were respectively, 4.91±6.78, 15.55±13.49 and19.04 ±14.57 ng/mL. Conclusion: Hyperleptinemia and anthropometric indices are the most prominent indicators of T2DM in individuals with a history of diabetes in the family
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