Abstract
Einleitung: Alcohol dependence (AD) contributes substantially to the global burden of disease. It's etiology involves both environmental and genetic factors with an estimated heritability of around 50%. Several lines of evidence suggest that the neuropeptide Y system plays a role in ethanol consumption: NPY knock-out mice consumed more alcohol than the wild-type, and NPY infusion reduced ethanol intake in rats. A recent study reported that activation/inhibition of the NPF system reduced/strengthened ethanol preference in drosophila. NPF receptors in drosophila are homologs of human NPY receptors. Following this rationale, we tested the genes encoding NPY and its receptors for association with AD in a large GWAS on AD.
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