Abstract
Bovine tuberculosis (bTB) is a global zoonotic disease that has detrimental economic impacts worldwide. The NOS2A gene plays a key role in immunological control of many infectious diseases. However, research on the association between NOS2A polymorphisms and bTB infection in Holstein cattle reared on the Yunnan-Guizhou plateau of China is scarce. This study investigated a possible linkage between NOS2A polymorphisms and risk of developing bTB in Chinese Holstein cattle. The NOS2A gene was genotyped in 144 bTB-infected Holstein cows and 139 healthy controls were genotyped through nucleotide sequencing. Ten single-nucleotide polymorphisms (SNPs) were detected, six of which were associated with susceptibility/resistance patterns of bTB. Furthermore, the C/T genotypes of 671 and 2793, and T/T genotype of E22 (+15) were significantly associated with susceptibility risk; the G/A genotype of 2857, T/T genotype of E9 (+65), and C/C genotype of E9 (+114) probably increased resistance to bTB. In addition, the haplotypes of NOS2A-2 and NOS2A-9 were risk factors for bTB susceptibility, while the NOS2A-5 and NOS2A-8 haplotypes were contributing protective variants against tuberculosis. There is a significant association between variation in SNPs of NOS2A and tuberculosis susceptibility/resistance pattern. These findings suggest that substitution of genetic selection would be helpful for eradicating bTB. However, further investigation is required to study the underlying mechanism through which NOS2A polymorphisms affect bTB infection.
Highlights
Bovine tuberculosis is a chronic infectious disease of great concern in cows
The disease is caused by the Mycobacterium tuberculosis pathogen. Bovine Tuberculosis (bTB) has been documented in many countries, including England, Ireland, Brazil, and China [1,2,3,4], where it causes large financial losses to the cattle industry and poses a threat to the health of human beings and wild animals [5]
Logistic regression was used to investigate the association between single loci of Single nucleotide polymorphism (SNP) and bTB susceptibility
Summary
Bovine tuberculosis (bTB) is a chronic infectious disease of great concern in cows. The disease is caused by the Mycobacterium tuberculosis pathogen. BTB has been documented in many countries, including England, Ireland, Brazil, and China [1,2,3,4], where it causes large financial losses to the cattle industry and poses a threat to the health of human beings and wild animals [5]. NOS2A polymorphisms associates susceptibility to tuberculosis in cattle
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