Abstract
BackgroundMyocardial infarction (MI) is one of the major causes of death and disability in the world. AimWe studied the functional polymorphisms of IL17A (HGNC:5981) G197A (rs2275913; NC_000006.11:g.52051033G > A) and −94 NFKB1 (HGNC:7794) ATTG ins/del (rs28362491, NC_000004.12:g.102500998_102501001ATTG) in patients with MI. MethodsThe selected polymorphisms were assessed in 201 MI patients and 201 healthy blood donors from Fars Province. Associations between allele frequencies, serum CXCL1 levels and clinicopathological criteria of MI were examined. ResultsA significant increase in del minor allele of NFKB1 in individuals with a BMI lower than 25 (P = 0.048) and in patients who needed coronary artery bypass graft during the course of treatment (P = 0.044) was observed. Also we found a significant association between plasma content of CXCL1 and -94 NFKB1 ATTG ins/del (rs28362491) polymorphism (P = 0.01). A trend of increase in the IL17A A-allele in patients with left ventricular hypertrophy and those with apical hypokinesia was observed as well. ConclusionThe minor alleles of genes upstream and downstream of IL-17A pathway are associated with BMI and clinicopathological parameters of MI severity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
