Abstract
The endothelium of the high endothelial venules (HEVs) of lymph nodes is normally considered to inhibit an association with neutrophils. The present paper shows that for a few weeks after birth, however, neutrophils are commonly associated with the walls of HEVs, the extent depending on the site of the lymph node. Overall, neutrophils increase in numbers in rat nodes from birth until about day 11, and vanish progressively thereafter. Moreover, neutrophils are more abundant in the nodes of standard neonates than in the nodes of pathogen-free neonates raised in an aseptic milieu. It is concluded that the postnatal recruitment of neutrophils by nodal HEVs relates to the then prevailing state of immaturity of the immune system. An explanation is proposed as to why neonatal HEVs of nodes recruit neutrophils and not only lymphocytes, as is the case later in ontogeny.
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