Abstract
Objective: In different studies, it has been shown that degenerative aortic stenosis and atherosclerosis had a common pathogenic mechanism. The goal of this study was to examine the association between NLR and the presence and severity of degenerative aortic valve stenosis. Methods : Echocardiographic data (from May 2011 to September 2013) of our cardiology department was reviewed retrospectively. After evaluation according to exclusion criteria’s, a total of 103 patients with degenerative AS and a control group of 35 age- and gender- matched patients who had normal echocardiographic findings were included in the study. Results: The level of NLR was highest in severe AS. The neutrophil-lymphocyte ratio was significantly higher in severe AS group than for the mild and moderate AS group (1.95±0.42, 2.31±0.69, 2.67±0.73; p<0.001 respectively). In comparison of the degenerative aortic stenosis groups with the control group, NLR in all aortic stenosis groups was found to be significantly higher than the control group (p<0.001). In addition, there was a statistically significant correlation between NLR and transaortic peak pressure gradient in patients with degenerative aortic stenosis (r: 0.626, p<0.001). Conclusion: The NLR, which is an inexpensive and readily available marker of chronic inflammation, may be useful in predicting the presence and severity of degenerative aortic stenosis.
Highlights
Aortic valve stenosis (AS) is most common valvular heart disease in developed countries (1)
Since chronic systemic inflammation plays an important role in the development of atherosclerosis, this process may play a critical role in the development and progression of degenerative aortic stenosis (2-4)
The goal of this study is to examine the association between neutrophil-lymphocyte ratio (NLR) and the presence and severity of degenerative aortic valve stenosis
Summary
Aortic valve stenosis (AS) is most common valvular heart disease in developed countries (1). It has been shown that degenerative aortic stenosis and atherosclerosis had a common pathogenic mechanism. It was shown that the neutrophil-lymphocyte ratio (NLR) is an important marker of inflammation in cardiac disorders, especially in atherosclerotic heart disease (5,6). The goal of this study is to examine the association between NLR and the presence and severity of degenerative aortic valve stenosis. The exclusion criteria’s were significant valvular heart disease (except for degenerative aortic valve disease), heart failure, presence of acute coronary syndrome, previous cardiac surgery, presence of atherosclerotic heart disease, malignancy, renal or hepatic failure, acute or chronic infectious disease, autoimmune disease, anemia (hemoglobin levels lower than 13 g/dl in men and 12 g/dl in women), pregnancy, recent blood transfusion, hematological disease, acute or chronic pulmonary disease, congenital and rheumatic aortic stenosis. Analyses were performed with PASW 18 (SPSS/IBM, Chicago, IL, USA) software and two-tailed P-value less than 0.05 was considered statistically significant
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