Abstract
Objective To explore the association of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism with weight gain induced by risperidone. Methods 356 patients with schizophrenia according to the DSM-IV criteria in this study. The height and body weight of the patients were measured before starting risperidone treatment and 8-week later. The MTHFRC677T polymorphism was genotyped using direct DNA sequencing method. Results A significant association was found between MTHFR gene C677T and body weight mass index (BMI) change after 8-week risperidone treatment. CC-carriers experienced higher BMI gain than CT/TT-carriers (CC(4.47±1.09), CT(4.54±1.27), TT(2.31±0.75), F=5.634, P 7%) was higher than that in non-bodyweight gain groups (48.4% vs 32.4%, χ2=11.342, P<0.01). Conclusion MTHFRC677T polymorphism is associated with risperidone induced weight gain in Chinese Han population. Key words: Schizophrenia; MTHFR gene; Antipsychotics; Body weight gain
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