Association of Mood Disorders, Substance Abuse, and Anxiety Disorders in Children and Teens With Serious Structural Eye Diseases

Abstract

We sought to evaluate the association between 5 eye diseases (including glaucoma, cataract, congenital optic nerve disease, congenital retinal disease, and blindness/low vision) and mental illness in a pediatric population. Cross-sectional study. A de-identified commercial insurance claims database, OptumLabs Data Warehouse, between January 1, 2007, and December 31, 2018, was used. Children and teens less than 19 years of age at the time of eye diagnosis were included. Demographics and mental illness claims were compared, looking at the association of mental illness and eye disease claims. A total of 11,832,850 children and teens were included in this study with mean age of 8.04 ± 5.94 years at the first claim. Of the patients with at least 1 of the 5 eye diseases (n=180,297), 30.5% had glaucoma (n=54,954), 9.5% had cataract (n=17,214), 21.4% had congenital optic nerve disease (n=38,555), 26.9% had congenital retinal disease (n=48,562), and 25.9% had blindness or low vision (n=46,778). There was a statistically significant association, after adjusting for confounding variables, between at least 1 of the 5 eye diseases and schizophrenia disorder (OR=1.54, 95% CI=1.48-1.61, P < .001), anxiety disorder (OR=1.45, 95% CI=1.43-1.48, P < .001), depressive disorder (OR=1.27, 95% CI=1.25-1.29, P < .001), and bipolar disorder (OR=1.27, 95% CI=1.21-1.31, P < .001), but a reversed association with substance use disorder (OR=0.88, 95% CI=0.86-0.90, P < .001). We found associations between eye disease in children and teens and mental illness. Understanding these relationships may improve mental illness screening and treatment in the pediatric population.