Abstract
BackgroundPrevious studies proposed that chronic inflammation in diabetes has a role in abnormal collagen production and elastin degradation, which promotes arterial stiffness. Monocyte-to-High Density Lipoprotein cholesterol ratio (MHR) is a simple measurement associated with inflammation and oxidative stress. However, little is known about the relationship of MHR with arterial stiffness. This study aimed to determine the association of MHR with arterial stiffness in patients with diabetes.MethodsA total of 81 patients with type 2 diabetes mellitus were enrolled in a cross-sectional study. Arterial stiffness factor in this study was Cardio Ankle Vascular Index (CAVI). We analyzed complete blood count and lipid profile in all participants, then performed statistical analysis to determine the relationship between MHR and CAVI. Receiver operating characteristic (ROC) analysis was used to estimate the cut-off values of MHR to predict CAVI ≥ 9.ResultsMedian of MHR in this study was 11.91 with the mean of CAVI was 8.13 ± 0.93. Spearman correlation analysis revealed a significant positive correlation between MHR and CAVI (ρ = 0.239, p = 0.031). Multivariate analysis showed the independent association of MHR to arterial stiffness (β = 0.361, 95% CI 0.023–0.093) and to CAVI ≥ 9 (OR 1.181, 95% CI 1.047–1.332). The cut-off values of MHR for predicting CAVI ≥ 9 were identified as ≥ 13 (OR 3.289, 95% CI 1.036–10.441).ConclusionMHR is associated with CAVI in patients with diabetes, irrespective of various potential confounders.
Highlights
Previous studies proposed that chronic inflammation in diabetes has a role in abnormal collagen production and elastin degradation, which promotes arterial stiffness
The mean of Cardio Ankle Vascular Index (CAVI) increased in age 30 to 69, was higher in male, uncontrolled diabetes and in active smoker (Fig. 2)
In this pilot study, we found that there was a positive correlation of Monocyte-to-High Density Lipoprotein cholesterol ratio (MHR) with arterial stiffness, which was measured by CAVI in patients with diabetes
Summary
Previous studies proposed that chronic inflammation in diabetes has a role in abnormal collagen production and elastin degradation, which promotes arterial stiffness. Little is known about the relationship of MHR with arterial stiffness. This study aimed to determine the association of MHR with arterial stiffness in patients with diabetes. Patients with diabetes mellitus (DM) are at higher risk of vascular complications. Arterial stiffness is the result of complex interactions of cellular and structural elements of vessel walls. Especially through inflammation stimulation, causes an excess production of abnormal collagen and elastin diminution [5]. Arterial stiffness is found as an independent predictor of cardiovascular events [6]. The multicentre observational Rebound study showed that the increasing of arterial stiffness predict the Mayasari et al BMC Cardiovasc Disord (2021) 21:362
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