Abstract
Myeloperoxidase (MPO) is a heme-containing peroxidase found in azurophilic granules of neutrophils and monocytes. Epidemiological studies have reported greater plasma MPO concentration to be associated with increased incidence of several cardiovascular diseases (CVD), but the association of intracellular monocyte MPO (mMPO) with CVD is unclear. The prospective population-based Atherosclerosis Risk in Communities (ARIC) cohort study measured mMPO using flow cytometry in 1,465 participants. The association of mMPO with incident cardiovascular disease (CVD, comprising incident coronary heart disease (CHD), heart failure, stroke, peripheral artery disease, and cardiovascular mortality) was examined over a median 9.6 years of follow-up (n = 290 CVD events). There was no statistically significant association between mMPO and all incident CVD events in either age, sex, and race-adjusted proportional hazards models (HR (95% CI) across tertiles of mMPO: 1, 1.09 (0.76, 1.57), and 0.78 (0.52, 1.15), P-trend = 0.21) or adjusted for other major CVD risk factors (HR (95% CI): 1, 1.17 (0.81, 1.69), and 0.87 (0.58, 1.29), P-trend = 0.50). There also was no association between mMPO tertiles and incident CHD, heart failure, or all-cause mortality, examined separately. In conclusion, intracellular monocyte myeloperoxidase was not associated with incident cardiovascular disease in this prospective population-based study.
Highlights
Myeloperoxidase (MPO) is a heme-containing peroxidase expressed largely by cells of the myeloid lineage [1,2]
The rates appear lower in tertile 3 compared to tertiles 1 and 2, we found no statistically significant association between monocyte MPO (mMPO) and all incident cardiovascular disease (CVD) events; adjusted for age, race, and sex (Model 1), the HR was 0.78 (0.52, 1.15) for participants with mMPO in tertile 3 compared to individuals in Monocyte Myeloperoxidase median fluorescence intensity (MFI) Tertiles
There was no association between mMPO tertiles and incident CHD or all-cause mortality. In this prospective population-based study, we found that a lower level of intracellular mMPO was not associated with an increased risk of CVD
Summary
Myeloperoxidase (MPO) is a heme-containing peroxidase expressed largely by cells of the myeloid lineage [1,2]. It is found mostly in azurophilic granules of neutrophils and monocytes, and to some extent in Kupffer cells, microglia, granule-containing neurons, and pyramidal neurons of the hippocampus [1]. It is released into extracellular fluids during its synthesis and in the setting of inflammation [3,4]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
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