Association of MMP9, MMP13 and MMP20 genes polymorphism with dental caries: A meta-analysis

Abstract

Genetic factors can be involved in dental caries as the most common chronic oral diseases . The association between polymorphism of MMP9 , MMP13 and MMP20 genes with tooth decay has been studied but contradictory outcomes have been indicated. Thus, a meta-analysis was done to get comprehensive outcomes in this path. All articles in English by March 2022 were searched with correlated keywords from known database as PubMed, Scopus, Embase and Web of Science, and the articles were selected in several stages based on exclusion and inclusion criteria. Comprehensive meta-analysis software v.2.0 was used for Meta-analysis. Finally, 11 related articles were selected for meta-analysis. According to the results, MMP9 and MMP20 polymorphisms were not related with increased susceptibility to caries in the studied models, but in the case of MMP13, a significant association was observed between gene polymorphism and caries risk. The results about MMP13 gene polymorphism showed that guanine G allele and GG genotype have a protective role and decrease the risk of dental caries. It should be noted that, these conclusions could be promoted by studies contain large sample sizes. Finding the genetic factors influencing tooth decay can help increase our current knowledge of caries pathology, predict its occurrence, and target genes at the molecular level to prevent it. • Meta-analysis showed that MMP9 and MMP20 polymorphisms were not related with tooth caries susceptibility. • There was a significant association between MMP 13 gene polymorphism and caries risk. • The results for MMP13 showed that GG genotype and G allele had a protective role and reduced the risk of caries.