Abstract
The genetic analysis of PCR-RFLP technique determined the genotype of miR-499gene, which found that the homozygote (AA) pattern was significantly higher in patients than in control group. On the other hand, the statistical analysis for the role of microRNAs genes in the hormones and physiological parameters above found that thehomozygote (AA) pattern of miR-499gene show more effects in changes of parameters (cortisol, testosterone, estradiol, insulin, glucagon, Fasting Blood Glucose (FBG), insulin resistance, insulin sensitivity, microalbuminuria systolic and diastolic pressure).
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