Abstract
Objective: To investigate whether microRNAs genes’ polymorphisms are associated with arthritis. Methods: The PubMed, Cochrane Library et al. were systematically searched to identify case–control studies, systematic reviews and meta-analyses. A meta-analysis was performed to calculate odds ratios (ORs), and confidence intervals (CIs) at 95% using fixed-effect model or random-effects model. Results: Twenty-two case–control studies involving 10489 participants fulfilled the inclusion criteria. MiR-146a rs2910164 (G/C) was not significantly associated with the risk of rheumatoid arthritis (RA) in any model. Significant associations were found between miR-146a rs2910164 (G/C) and the risk of psoriatic arthritis (PsA) in the heterozygous model and the dominant model. The heterozygous model showed a significant association between the miR-146a rs2910164 (G/C) polymorphism and ankylosing spondylitis (AS). And there was no significant association of miR-146a rs2910164 (G/C) with risk of juvenile rheumatoid arthritis (JRA) at any model. Additionally, there was a significant association of miR-499 rs3746444 (T/C) with risk of RA at two genetic models, and with a moderate heterogeneity. When subgroup analysis by ethnicity, significant associations were almost found between miR-499 rs3746444 (T/C) and the risk of RA in any model in Caucasian populations, and there is no heterogeneity. Conclusions: The association of miR-146a rs2910164 (G/C) with RA was not found. And there was a significant association between miR-146a rs2910164(G/C) and PsA or AS. MiR-499 rs3746444 (T/C) was associated with RA in Caucasian populations. These findings did not support the genetic association between miR-146a rs2910164 (G/C) and JRA susceptibility, as well as the association of miR-196a-2 rs11614913 (C/T), miR-146a rs2431697, miR-146a rs57095329, miR-149 rs22928323 with arthritis.
Highlights
Arthritis is a general term for acute or chronic inflammatory diseases of joint [1]
Of the 22 studies that were included in the meta-analyses, there were a total of 10489 participants (4509 cases and 5980 controls) involving six single nucleotide polymorphism (SNP) of microRNAs: miR-146a rs2910164, miR-499 rs3746444, miR-196a-2 rs11614913, miR-146a rs2431697
Zhou et al [35] reported that miR-146a rs2910164 (G/C) polymorphism was associated with rheumatoid arthritis (RA) in female population, with the heterozygote CT having a more severe and more active form of disease compared with other genotypes
Summary
Arthritis is a general term for acute or chronic inflammatory diseases of joint [1]. Common types include diseases such as rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), juvenile rheumatoid arthritis (JRA) and other forms of arthritis. Arthritis is characterized by the progression of synovial inflammation leading to joint destruction [2], causing complications such as pain and limited activity, resulting in continuous impairment of physical function and quality of life [3]. The muscle atrophy of children with JRA progresses rapidly, leading to skeletal developmental disorders, affecting their growth and development. Patients with arthritis may need more social and nursing care. The increased social and economic burdens associated with arthritis worldwide make their targeting treatment a major public health goal
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