Abstract
PurposeMany reports suggest the correlation between altered microRNA level and the pathogenesis of glaucoma. It is suspected that disruption in microRNA processing machinery may influence microRNAs action. The single nucleotide polymorphisms in genes DGCR8 and XPO5, which are involved in microRNA biogenesis may be the key factor in this process.MethodsThe blood samples of 80 patients affected by primary open angle glaucoma and 250 age matched controls were enrolled to this study. The DNA was isolated from the peripheral blood lymphocytes. The polymorphic variant frequencies of DGCR8 (rs 3757) and XPO5 (rs 1107) genes were determined using TaqMan® SNP Genotyping Assays.ResultsThe statistical analysis revealed that the polymorphism of DGCR8 gene did not affect to the risk of primary open angle glaucoma. While, the TT genotype of XPO5 was found to be present mainly in patients not affected by glaucoma (P=0.049746).ConclusionsIn conclusion, it was evaluated that the TT genotype of XPO5 gene might have protective effect on the risk of primary open angle glaucoma. Therefore, future analysis of polymorphic variants of genes involved in microRNA biogenesis could be used for patient's diagnosis according to glaucoma occurence.
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