Abstract
Association of microRNA-146a and their target gene IRAK-1 polymorphism with enthesitis related arthritis category of juvenile idiopathic arthritis
Highlights
MicroRNAs are non-coding RNA molecules that play pivotal role in modulating the expression of multiple target genes at the post-transcriptional level
Taking into account that interleukin-1 receptor-associated kinase-1 (IRAK-1) is a target of miR-146a, we studied the association between Single Nucleotide Polymorphisms (SNP) of miRNA-146 and its target IRAK-1 with susceptibility to Juvenile Idiopathic Arthritis-Enthesitis Related Arthritis (JIA-ERA)
One hundred and fifty patients with JIA-ERA (ILAR criteria) were included in the study. 216 blood donors (201 male) with a mean age of 30.5 years served as controls. miR-146a (C/G) and it’s target IRAK-1(C/T) at Exon 12 region and IRAK-1 (A/C) at 3’UTR polymorphisms were analyzed using PCR-RFLP method
Summary
MicroRNAs (miRNAs) are non-coding RNA molecules that play pivotal role in modulating the expression of multiple target genes at the post-transcriptional level. Single Nucleotide Polymorphisms (SNP) in pre-miRNAs can alter miRNA expression, and polymorphism in target molecules can affect binding to target mRNA. Studies have shown an association between miR-146a polymorphisms and autoimmune disease. Taking into account that interleukin-1 receptor-associated kinase-1 (IRAK-1) is a target of miR-146a, we studied the association between SNPs of miRNA-146 and its target IRAK-1 with susceptibility to Juvenile Idiopathic Arthritis-Enthesitis Related Arthritis (JIA-ERA)
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