Abstract
A hundred and eighteen patients aged 45-60 years who had type 2 diabetes (T2D) with and without coronary heart disease (CHD) were examined to study the frequency of the methylenetetrahydrofolate reductase (MTFR) C677T gene polymorphism in T2D and its association with the level of homocysteine (HC) and the development of myocardial infarction (MI). A control group included 89 blood donors. Statistically significant differences were found in the frequency of alleles T677 and C677, genotype C677C between the groups of patients with T2D, CHD, and prior MI and the control group. Allele T677 of the MTFR gene was associated with a higher risk of MI in patients with T2D (OR = 1.879; p = 0.029). A combination of genotype T677T of the MTFRgene with hyper-homocysteinemia in patients with T2D is closely related to other risk factors of cardiovascular diseases and may have a significant impact on the course of CHD.
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