Abstract
To examine and evaluate the relationships of the metabolic syndrome and abnormalities of bulbar conjunctival vessels among middle-aged Kaunas population. Analysis was performed on 383 asymptomatic persons aged 38-39 years (170 men and 212 women). Metabolic syndrome was defined using criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). For determination of abnormalities in bulbar conjunctiva vessels and microcirculation, each participant underwent noncontact slit lamp examination. The changes of vessel walls and bloodstream, extravasal alterations were evaluated, and conjunctival index was calculated. Metabolic syndrome was present in 10.7% of individuals. Persons with metabolic syndrome had a 2.35-point higher conjunctival index compared to the controls (P=0.003). After evaluation of various components of metabolic syndrome to conjunctival index, it was determined that the greatest change in the means of conjunctival index was due to hyperglycemia (P=0.02) and central obesity (P=0.05). Metabolic syndrome was related to venular dilatation (OR=3.78; 95% CI, 1.86-7.72), arteriolar narrowing (OR=1.98; 95% CI, 0.97-4.09), decreased arteriolar-venular ratio (OR=2.35; 95% CI, 1.13-4.98), and increased venular tortuosity (OR=2.24; 95% CI, 1.06-4.82). Multiple logistic analysis revealed that venular dilatation (OR=3.38; 95% CI, 1.43-7.99) and arteriolar narrowing (OR=2.22; 95% CI, 0.98-5.01) were significant factors in the prognosis of metabolic syndrome. Metabolic syndrome was significantly related to abnormalities of bulbar conjunctival vessels such as venular dilatation, arteriolar narrowing, decreased arteriolar-venular ratio, and increased venular tortuosity. Both conjunctival index and individual conjunctival microvascular changes may be prognostic factors for metabolic syndrome, but long-term studies on associations between metabolic syndrome and changes of bulbar conjunctival vessels are needed.
Highlights
Persons with metabolic syndrome had a 2.35-point higher conjunctival index compared to the controls (P=0.003)
After evaluation of various components of metabolic syndrome to conjunctival index, it was determined that the greatest change in the means of conjunctival index was due to hyperglycemia (P=0.02) and central obesity (P=0.05)
Metabolic syndrome was related to venular dilatation (OR=3.78; 95% CI, 1.86–7.72), arteriolar narrowing (OR=1.98; 95% CI, 0.97– 4.09), decreased arteriolar-venular ratio (OR=2.35; 95% CI, 1.13–4.98), and increased venular tortuosity (OR=2.24; 95% CI, 1.06–4.82)
Summary
Metabolinio sindromo ir jo komponentø sàsajos su akies obuolio junginës kraujagysliø pokyèiais. Raktaþodþai: metabolinis sindromas, akies obuolio junginës kraujagyslës, konjunktyvinis indeksas, rizikos veiksniai. Nustatyti ir ávertinti metabolinio sindromo ir jo komponentø sàsajas su akies obuolio junginës kraujagysliø pokyèiais tarp vidutinio amþiaus Kauno miesto gyventojø. Metabolinis sindromas labiausiai susijæs su venø iðsiplëtimu Daugiafaktorinë logistinë analizë parodë, kad metaboliniam sindromui prognozuoti buvo reikðmingi du junginiø kraujagysliø poþymiai: iðsiplëtæs venø Metabolinis sindromas yra reikðmingai susijæs su ðiais akies obuolio junginës kraujagysliø pokyèiais: venø iðsiplëtimu, arterijø susiaurëjimu, sumaþëjusiu arterijø ir venø skersmens santykiu, padidëjusiu venø vingiuotumu. Ðio darbo tikslas – nustatyti akies obuolio junginës smulkiøjø kraujagysliø pokyèiø ryðá su metaboliniu sindromu ir jo komponentais. Akies obuolio junginës kraujagysliø tyrimo metodai 1. Abi akys tirtos nekontaktiniu bûdu padidinus 18, 35 ir 60 kartø, ávertintos junginiø kraujagyslës ir mikrocirkuliacija iðoriniuose (virðutiniame ir apatiniame) bei vidiniuose (virðutiniame ir apatiniame) akies obuolio segmen-
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