Association of Metabolic Syndrome Components and Overactive Bladder in Women.

Corc Baytaroglu,Emrah Sevgili

doi:10.7759/cureus.14765

Abstract

BackgroundTo identify associations between metabolic syndrome (MS) components and overactive bladder (OAB) in women.MethodologyThe present study was conducted prospectively between February 2021 and April 2021 and included the assessment of women admitted to the cardiology outpatient clinic and their female relatives. Records were made of the demographic characteristics of patients and blood tests, including cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), triglyceride, and fasting glucose levels (FG). In addition, the score on the Overactive Bladder Questionnaire-8-item (OAB-V8) form was noted. The study population was divided into two groups according to OAB-V8 score. The groups were compared in terms of participant demographic properties, OAB-V8 scores, metabolic component values, and blood test results.ResultsIn total, 200 participants with a mean age of 49.8 years were enrolled in the study. Participants with OAB had significantly higher body mass index (BMI) (30.1 kg/m2 versus 27.1 kg/m2; p = 0.001) and longer waist circumference (97.8 cm versus 89.0 cm; p = 0.001). Similarly, the mean FG and LDL levels were significantly higher in participants with OAB (p = 0.001 and p = 0.001). Lastly, mean OAB-V8 score was 20.2 for participants with OAB and 4.8 for participants without OAB. Multivariate regression analysis showed that higher BMI and longer waist circumference were significantly associated with OAB (1.228-fold; p = 0.001 and 1.058-fold; p = 0.001, respectively). Additionally, multivariate regression analysis found that higher LDL level and FG were predictive factors for OAB (1.115-fold; p = 0.003 and 1.229-fold; p = 0.001, respectively).ConclusionsThe present study found that higher BMI, longer waist circumference, and higher LDL and FG levels were predictive factors for OAB development in women.

Highlights

Overactive bladder (OAB) is characterized by voiding urgency, frequency, and nocturia, with or without urinary incontinence, in the absence of pathologies that can cause these symptoms [1]
Multivariate regression analysis showed that higher body mass index (BMI) and longer waist circumference were significantly associated with overactive bladder (OAB) (1.228-fold; p = 0.001 and 1.058-fold; p = 0.001, respectively)
Multivariate regression analysis found that higher low-density lipoproteins (LDL) level and fasting glucose levels (FG) were predictive factors for OAB (1.115-fold; p = 0.003 and 1.229-fold; p = 0.001, respectively)

Summary

Introduction

Overactive bladder (OAB) is characterized by voiding urgency, frequency, and nocturia, with or without urinary incontinence, in the absence of pathologies that can cause these symptoms [1]. The true incidence of OAB is still unknown, and previous studies have reported OAB incidence in a wide range [3]. The pathophysiology of OAB is not well understood, and morphologic changes in detrusor muscle, neuroplasticity, inflammation, and pelvic ischemia are believed to be among the underlying factors [4]. Many studies have investigated the correlation between OAB and other diseases, including glucose intolerance, hypertension, nervous system diseases, and metabolic syndrome (MS) [5,6]. Due to the effects of MS such as glucose intolerance and pelvic ischemia, its relationship with urological diseases is under close observation. To identify associations between metabolic syndrome (MS) components and overactive bladder (OAB) in women

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