Association of MBL2 gene polymorphisms and systemic lupus erythematosus susceptibility: A meta-analysis.

Abstract

Mannose binding lectin (MBL) gene single nucleotide polymorphisms have been associated with systemic lupus erythematosus (SLE) risk with inconsistent results. This study aimed to explore whether MBL2 A\B, A\C, A\D, A\O, L\H and Y\X polymorphisms affected SLE susceptibility. A meta-analysis was performed on 20 studies, containing allelic contrast, additive, dominant and recessive models. Odds ratio (OR) was calculated to reflect the effect of association. A total of 64 pooled comparisons were conducted, including 7194 SLE patients and 7401 healthy controls. The meta-analysis inducted a significant association between allele B and SLE (OR=0.766, 95% CI=0.681-0.862, P<.001). The genotype BB in the additive model and AB+BB in the recessive model both reduced the risk of SLE (OR=0.611, 95% CI=0.422-0.882, P=.009; OR=0.806, 95% CI=0.688-0.944, P=.008). Regarding A\O polymorphisms, results revealed statistical differences in allelic contrast, additive model and recessive models (OR=0.826, 95% CI=0.732-0.931, P=.002; OR=0.737, 95% CI=0.557-0.977, P=.034 and OR=0.793, 95% CI=0.683-0.921, P=.002, respectively). As for L\H, meta-analysis revealed that allele H and genotype HH both decreased SLE susceptibility in allelic contrast and dominant models (OR=1.463, 95% CI=1.097-2.007, P=.018; OR=1.383, 95% CI=1.124-1.701, P=.002). Stratification by ethnicity indicated that allele H related to SLE in European populations (OR=0.736, 95% CI=0.617-0.879, P=.001), and the recessive model correlated with SLE in Asians (OR=0.808, 95% CI=0.667-0.979, P=.03). The present study suggests that A\B and A\O polymorphisms were associated with SLE susceptibility, and the allele H may be a protective factor in SLE.