Abstract
BackgroundMaternal fatty acids (FAs) intake has an effect on birth weight, birth length, and gestational age, as fetal development is entirely dependent on the maternal essential FA supply. This study aimed to identify the association between the maternal intake of FAs and birth outcomes among pregnant women who participated in the Mothers and Children’s Environmental Health (MOCEH) prospective cohort study in South Korea.MethodsA total of 1407 pregnant women, aged 30.2 ± 3.7 years, at 12 to 28 weeks’ gestation were recruited between August 2006 and December 2010. Their dietary intake during pregnancy was investigated by the 1-day 24-h dietary recall method. The pregnancy outcome data—namely infant’s gestational age, birth weight, and birth length—were analyzed for their associations with their mothers’ intake of FAs.ResultsWhen adjusted for confounding factors, multiple regression analysis revealed adverse effects on birth weight (P = 0.031) and birth length (P = 0.025) with high maternal intake of omega-6 FAs. In the multiple logistic regression analysis, the odds ratio (OR) for the risk of being below the 10th percentile for birth weight was higher in the highest quintile (Q5) compared to the lowest quintile (Q1) of omega-6 FA intake levels (OR = 2.444; 95% CI = 1.038–5.751; P for trend = 0.010). Also, the OR for being above the 90th percentile of birth length was lower in the highest quintile (Q5) compared to that in the lowest quintile (Q1) of omega-6 FA intake (OR = 0.432; 95% CI = 0.211–0.884; P for trend = 0.020). However, the maternal intake of omega-3 FAs was not related to gestational age, birth weight, or birth length.ConclusionsA high maternal omega-6 FA intake was negatively associated with birth weight and birth length.
Highlights
Maternal fatty acids (FAs) intake has an effect on birth weight, birth length, and gestational age, as fetal development is entirely dependent on the maternal essential FA supply
A high maternal omega-6 FA intake was negatively associated with birth weight and birth length
Many studies have demonstrated a link between maternal fatty acids (FAs) intake and pregnancy outcomes, including infant’s birth weight and birth length
Summary
Maternal fatty acids (FAs) intake has an effect on birth weight, birth length, and gestational age, as fetal development is entirely dependent on the maternal essential FA supply. Many studies have demonstrated a link between maternal fatty acids (FAs) intake and pregnancy outcomes, including infant’s birth weight and birth length. Despite these findings, the mechanisms underlying the correlation between maternal FAs intake and fetal size have not been fully elucidated. Deficiencies in the levels of the mothers’ FAs intake could have negative outcomes on the birth weight, birth length, and gestational age of the infant, as fetal development is entirely dependent on the. Other studies have shown conflicting results [12,13,14].
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