Abstract
Maternal diabetes (MDM) during pregnancy affects the future metabolic health of the offspring. One possible mechanism by which MDM could enduringly impact offspring health is via an effect on the fetal brain. Specifically, we hypothesize that in utero exposure to MDM contributes to long-term alterations in offspring brain microstructure, through an inflammatory process called gliosis, within the energy regulatory centers of the mediobasal hypothalamus (MBH). MBH gliosis, quantifiable by MRI, is associated with increased adiposity and insulin resistance in children and adults.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
