Association of maternal and fetal genotypes of rs5396 polymorphism of solute carrier family 2,member 2 gene in women with gestational diabetes mellitns

Abstract

Objective To elucidate the influence of fetal solute carrier family 2, member 2(SLC2A2) genotype on both non-diabetic pregnant women and pregnant females with GDM. MethodsIn this case-control study, anthropometric and metabolic variables of 75 non-diabetic pregnantcontrols with their 39 fetuses and 51 GDM women with their 23 fetuses were compared on the basis ofSLC2A2 rs5396 polymorphism. Results (1) The frequency of AA genotype of site rs5396 was86. 3% in GDM mothers group, which was significantly increased compared with that of the controlmothers group (70. 7% , P 0.05). (3) There was no statistical difference in the proportion of AA-AAmother-fetus genotype pairs between the GDM and control group (50. 0% vs 55. 0%, P = 0. 720).Conclusions rs5396 polymorphism in SLC2A2 gene of pregnant women may contribute to the genesisof GDM, but no evidence shows that the fetal polymorphism in this gene is associated with GDM. Key words: Diabetes, gestational; Genetic predisposition to disease; Polymorphism, single nucleotide; Glucose transporter type 2; Genotype