Abstract
BackgroundTo investigate whether macular structure could be affected by axial elongation and to determine the association between macular intraretinal thickness and the microstructure of β-zone parapapillary atrophy (PPA) in myopic eyes.MethodsThe study recruited 113 healthy myopic subjects (113 eyes). Images of the macula, subfoveal choroid, and optic nerve head were acquired using spectral-domain optical coherence tomography (SD-OCT). An automatic segmentation algorithm was used to segment the macular images into 7 intraretinal layers. PPA widths with and without Bruch’s membrane (PPA+BM and PPA-BM, respectively) were evaluated. Linear regression analysis was performed to evaluate the association between macular intraretinal thickness and axial length and the microstructure of PPA.ResultsAn increase in axial length was associated with a decrease in whole macular thickness of the peripheral region and an increase in whole macular thickness of the central region. Thickness alterations of the macular intraretinal layers were most apparent in the peripheral region. A significant correlation was found between PPA-BM width and macular intraretinal layer thickness, whereas no significant correlation was found between PPA+BM width and macular intraretinal layer thickness. Moreover, both PPA+BM and PPA-BM widths significantly correlated with subfoveal choroidal thickness.ConclusionsMacular intraretinal layer thickness may be affected by PPA-BM width. These findings indicate that the microstructure of PPA should be considered when evaluating the macula in patient with myopia and glaucoma.
Highlights
To investigate whether macular structure could be affected by axial elongation and to determine the association between macular intraretinal thickness and the microstructure of β-zone parapapillary atrophy (PPA) in myopic eyes
A previous study showed that optic nerve head (ONH) tilt was associated with PPA+Bruch’s membrane (BM) and parapapillary atrophy with Bruch’s membrane (PPA-BM) widths, which suggested that the microstructure of PPA might reflect the myopic remodeling of the ONH [6]
In this study, we evaluated the association of each macular layer thickness with axial length and the microstructure of PPA in myopic eyes
Summary
To investigate whether macular structure could be affected by axial elongation and to determine the association between macular intraretinal thickness and the microstructure of β-zone parapapillary atrophy (PPA) in myopic eyes. Parapapillary atrophy (PPA) is common in myopic and glaucomatous eyes, which is classified into the peripheral α-zone and central β-zone on fundus photography. PPA can be classified into β-parapapillary atrophy with and without BM (PPA+BM and PPA-BM). Several clinic-based studies have shown that PPA+BM was mostly associated with glaucoma, older age, and myopia. PPA-BM was associated with a longer axial length but not with glaucoma [2,3,4,5]. A previous study showed that optic nerve head (ONH) tilt was associated with PPA+BM and PPA-BM widths, which suggested that the microstructure of PPA might reflect the myopic remodeling of the ONH [6]. PPA’s formation and significance are not fully understood
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